Years after a mysterious plague has devastated the planet and turned most of humanity into blood-hungry creatures, a rogue drifter on a vengeful hunt stumbles across a band of survivors in an abandoned police station and reluctantly agrees to try to help them defend themselves and escape to the sanctuary they so desperately need.
Following to an outbreak that turned most of mankind into vampire-zombie-like creatures, the few survivors have to fight the creatures and marauders. When a group that is rescuing a girl is killed by pillagers, a young woman called Samantha “Sam” Sheridan is spared to be raped by the criminals. However, the lonely driver Thomas Rourke kills the men and saves Sam. She offers ammunition, supplies, fuel and food if Rourke drives the girl and her to her hideout before the sunset. Rourke arrives in the dark but her group protects them from the creatures and Sam, Rourke and the girl arrive at the sanctuary in a former police station; but Rourke recognizes The Alpha that leads the creatures. The leaders Frank Hill, his son Ethan Hill and the former police officer Chris suspect of Rourke, but they promise to honor Sam’s promise. He is locked in a cell but during the night, a strong creature breaks in the building while the survivors hear noises outside. In the morning, they find that the creatures gave pulled wrecked cars in front of their garage and their cars are trapped inside the building. Rourke convinces a small group to go with him to the hide-out of the creatures to destroy The Alpha. Why Rourke is obsessed to kill The Alpha? Will they succeed in their intent?